Nephrotic Syndrome in Adults

Nephrotic Syndrome in Adults

Nephrotic syndrome is a condition marked by very high levels of protein in the urine; low levels of protein in the blood; swelling, especially around the eyes, feet, and hands; and high cholesterol. Nephrotic syndrome results from damage to the kidneys’ glomeruli (the singular form is glomerulus). Glomeruli are tiny blood vessels that filter waste and excess water from the blood and send them to the bladder as urine.

Nephrotic syndrome can occur with many diseases, including the kidney diseases caused by diabetes mellitus, but some causes are unknown. Prevention of nephrotic syndrome relies on controlling these diseases.

Treatment of nephrotic syndrome focuses on identifying the underlying cause if possible and reducing high cholesterol, blood pressure, and protein in urine through diet, medications, or both. One group of blood pressure medications called ACE inhibitors also protects the kidneys in diabetic patients.

Nephrotic syndrome may go away once the underlying cause, if known, has been treated. In children, 80 percent of nephrotic syndrome cases are caused by minimal change disease, which can be successfully treated with prednisone. However, in adults most of the time a kidney disease is the underlying cause, and these diseases cannot be cured. In these cases, the kidneys may gradually lose their ability to filter wastes and excess water from the blood. If kidney failure occurs, the patient will need dialysis or a kidney transplant.

More information is available from

American Kidney Fund
6110 Executive Boulevard
Rockville, MD 20852
Tel: (800) 638-8299

National Heart, Lung, and Blood Institute
Information Center
P.O. Box 30105
Bethesda, MD 20824-0105
Tel: (301) 592-8573
e-mail: mailto:nhlbiic@dgysys.com

National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Tel: (800) 622-9010

Additional Information on Nephrotic Syndrome

The National Kidney and Urologic Diseases Information Clearinghouse collects resource information on kidney and urologic diseases for the Combined Health Information Database (CHID). CHID is a database produced by health-related agencies of the Federal Government. This database provides titles, abstracts, and availability information for health information and health education resources.

To provide you with the most up-to-date resources, information specialists at the clearinghouse created an automatic search of CHID. To obtain this information you may view the results of the automatic search Nephrotic Syndrome.

Or, if you wish to perform your own search of the database, you may access the CHID Online web site and search CHID yourself.

National Kidney and Urologic Diseases Information Clearinghouse 3 Information Way
Bethesda, MD 20892-3580
E-mail: National Kidney and Urologic Diseases Information Clearinghouse

The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). NIDDK is part of the National Institutes of Health under the U.S. Department of Health and Human Services. Established in 1987, the clearinghouse provides information about diseases of the kidneys and urologic system to people with kidney and urologic disorders and to their families, health care professionals, and the public. NKUDIC answers inquiries; develops, reviews, and distributes publications; and works closely with professional and patient organizations and Government agencies to coordinate resources about kidney and urologic diseases.

Publications produced by the clearinghouse are carefully reviewed for scientific accuracy, content, and readability.

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NIH Publication No. 99-4624